Neuronal nitric oxide synthase in the lower reproductive tract of female Drosophila

Neuronal nitric oxide synthase in the lower reproductive tract of female Drosophila

MARIANA F. WOLFNER Department of Molecular Biology and Genetics Cornell University Ithaca, NY 14853 USA E-mail:[email protected] Nitric oxide (NO) plays important roles in numerous physiological processes in many animals. In mammals, NO regulates muscle contractions in the female reproductive tract [e.g. Ekerhovd et al. (1997) Hum. Repro. 12: 301-305; Yampalli et al. (1993) Endocrinol...

Physiologic role of nitric oxide and nitric oxide synthase in female lower urinary tract.

PURPOSE OF REVIEW In recent years nitric oxide (NO) has gained increasing recognition as an important neurotransmitter and cell signaling molecule with a broad range of functions in the lower urinary tract. This review discusses recently published data related to the physiologic and pathophysiologic roles of NO and nitric oxide synthase (NOS) in the female lower urinary tract. RECENT FINDINGS...

Macula densa neuronal nitric oxide synthase.

In the juxtaglomerular apparatus of the kidney the distal tubule returns to its own glomerulus where specialised cells, the macula densa (MD) cells, are located so that they come in contact with the tubular fluid. It is well documented that MD cells sense the distal tubular flow-rate and that when the flow is too high they are activated, which leads to vasoconstriction of the afferent arteriola...

Neuronal Nitric Oxide Synthase Is Necessary

Chlamydia trachomatis persistence in the female mouse genital tract: inducible nitric oxide synthase and infection outcome.

It was previously reported that female mice resolve a primary Chlamydia trachomatis urogenital infection independent of inducible nitric oxide synthase (iNOS). We now report that although iNOS-deficient (NOS2(-/-)) mice resolve culture-apparent infection in a fashion similar to that of normal control (NOS2(+/+)) mice, they sustain significantly increased rates of disease, as assessed by hydrosa...